Vertex lifts 2026 revenue guidance to $13.15–$13.25 billion on 12% quarterly growth

Vertex reported third-quarter 2026 total revenue of $3.44 billion, up 12% from a year earlier, with U.S. revenue of $2.17 billion and revenue outside the U.S. of $1.27 billion. The company raised full-year 2026 revenue guidance to $13.15 billion to $13.25 billion from $13.1 billion to $13.2 billion. GAAP net income fell to $654 million from $1.1 billion, reflecting roughly $500 million of compensation and transaction expenses tied to the Crinetics Pharmaceuticals acquisition, while non-GAAP net income was $1.2 billion in each third quarter.